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Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
Expression of metabolic modulators in tumor microenvironment to improve tumor therapy
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机译:肿瘤微环境中代谢调节剂的表达以改善肿瘤治疗
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摘要
Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF- 1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.
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