FOAMY VIRUSES AND METHODS OF USE

摘要

The disclosure provides methods and materials for treating cancer. For example, foamy viruses (e.g., simian foamy viruses) are provided as well as methods and materials for treating cancer using foamy viruses as an oncolytic agent. Specifically, the disclosure provides a chimeric simian foamy virus (SFV) comprising: a first genomic fragment of a first SFV strain; and a second genomic fragment of a second SFV strain. Further provided are methods for treating a mammal having cancer comprising administering to said mammal SFV having oncolytic anticancer activity.