BENZOFURAN UREAS OR CARBAMATES AND HETEROAROMATIC ANALOGUES THEREOF FOR USE IN THERAPY

摘要

The present invention relates to benzofuran ureas or carbamates of formula I and heteroaromatic analogues thereof as described below or a tautomer or a pharmaceutically acceptable salt thereof; to a pharmaceutical composition containing these compounds, and to these compounds for use in therapy, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization. Formula (I) wherein X¹ is CR¹ or N; X² is CR² or N; X³ is CR³ or N; X⁴ is CR⁴ or N; with the proviso that at most two of X¹, X², X³ and X⁴ are N; E¹ is O or NR^6a; E² is O or NR^6b;with the proviso that E¹ and E² are not simultaneously O; L¹ is a bond, optionally substituted C₁-C₆-alkylene or C₃-C₈-cycloalkylene; L² is a bond, optionally substituted C₁-C₆-alkylene, C₃-C₈-cycloalkylene, etc.; A is 3-, 4-, 5-, 6-, 7- or 8-membered saturated, partially unsaturated or maximally unsaturated carbocyclic ring or a 3-, 4-, 5-, 6-, 7- or 8- membered saturated, partially unsaturated or maximally unsaturated heterocyclic ring; or L²-A forms a group C₁-C₆-alkylene-OR¹³, C₁-C₆--alkylene-SR¹⁴ or C₁-C₆-alkylene-NR¹⁵R¹⁶; and R¹, R², R³, R⁴, R⁵, R^6a, R^6b, R¹³, R¹⁴, R¹⁵ and R¹⁶ are as defined in the claims and the description.