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Cold adapted and virulence factor deleted live attenuated vaccine suitable for mucosal delivery
Cold adapted and virulence factor deleted live attenuated vaccine suitable for mucosal delivery
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机译:冷适应和毒力因子缺失的减毒活疫苗适合粘膜递送
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摘要
Compositions and methods are provided for a live, attenuated influenza vaccine suitable for nasal administration. The vaccine utilizes a cold adapted influenza virus that lacks virulence factor, and includes mutations that provide replicative ability sufficient for vaccine manufacture. Vaccines so produced provide significant cross protection for non-vaccinating strains. The vaccine is safe for children under the age of 2 and adults over 49 years of age. In addition, the cold adapted, virulence factor deleted influenza virus can be adapted to provide immunity to non-influenza pathogens.
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