首页> 外国专利> ORALLY DISINTEGRATING TABLET HAVING SUPPRESSED BITTERNESS OF FAST DISSOLVING DRUG

ORALLY DISINTEGRATING TABLET HAVING SUPPRESSED BITTERNESS OF FAST DISSOLVING DRUG

机译:具有快速溶解药物苦味的口感可分解片剂

摘要

The present invention significantly reduces drug bitterness that is tasted in the mouth when an orally disintegrating tablet containing a drug having a fast dissolving speed is taken. Provided is an orally disintegrating tablet in which, in accordance with the dissolution test method (paddle method) of the Japanese Pharmacopoeia 17th Edition, the dissolution rate of a drug is in the range of 40.0-70.0% at a time point when five minutes has elapsed after start of the dissolution test that is performed using a dissolution test second fluid (obtained by adding one volume of water to one volume of a phosphate buffer solution at pH 6.8). The drug is desirably a memantine hydrochloride or a solifenacin succinate.
机译:当服用包含具有快速溶解速度的药物的口腔崩解片剂时,本发明显着降低了在口腔中滋味的药物苦味。提供一种口腔崩解片,其中,根据日本药典第17版的溶出度试验方法(桨式法),在5分钟的时间点药物的溶出度在40.0-70.0%的范围内。在开始使用溶出度测试第二种液体进行溶出度测试后经过的时间(通过向一体积的pH 6.8磷酸盐缓冲溶液中加入一体积的水获得)。理想地,该药物是盐酸美金刚或琥珀酸索非那新。

著录项

  • 公开/公告号WO2019098327A1

    专利类型

  • 公开/公告日2019-05-23

    原文格式PDF

  • 申请/专利权人 OHARA PHARMACEUTICAL CO. LTD.;

    申请/专利号WO2018JP42487

  • 发明设计人 TERADA HIROTO;

    申请日2018-11-16

  • 分类号A61K9/20;A61K31/13;A61K31/4725;A61K47/32;A61K47/38;A61P25/28;

  • 国家 WO

  • 入库时间 2022-08-21 11:54:42

获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号