NOVEL ELECTROSPUN SYNTHETIC DENTAL BARRIER MEMBRANES FOR GUIDED TISSUE REGENERATION AND GUIDED BONE REGENERATION APPLICATIONS

摘要

The present disclosure describes membranes suitable for use as guided tissue regeneration (GTR) barrier membranes and guided bone regeneration (GBR) barrier membranes in dental applications that are composed of fibrous and highly porous biodegradable materials fabricated using electrospinning and that may be surface-modified with plasma treatment or other suitable methods of surface-modification. The disclosed membranes have a high surface area to volume ratio. The use of the disclosed GTR barrier membranes or GBR barrier membranes provides a barrier that prevents the migration of soft tissue cells but is permeable to small molecules such as nutritional substances and medications. Methods of fabricating the disclosed resorbable barrier dental membranes for GTR and GBR applications using electrospinning are also disclosed. The disclosed membranes may have precisely tuned physical, chemical, and mechanical properties optimized for various GTR and GBR applications.