CAR-T CELL TARGETING CD19 AND EXPRESSING CD40 ANTIBODY AT HIGH LEVEL OF STABILITY, AND USE THEREOF

摘要

A CAR-T cell that targets CD19 and that expresses a CD40 antibody at a high level of stability, and a use thereof. The CAR-T cell contains a coding sequence for a chimeric antigen receptor that recognizes CD19 and a coding sequence for a CD40 activation antibody; and/or a chimeric antigen receptor that expresses and recognizes CD19 and a CD40 activation antibody. After the antibody and the CD40 antigen are combined, a costimulatory signal may be launched, promoting the activation and proliferation of CAR-T cells in vivo, and increasing the anti-tumor killing effect of cytotoxic T cells, thereby improving the efficacy of specifically killing tumors.