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MONOCLONAL ANTIBODIES TARGETING MICROTUBULE-BINDING DOMAIN OF TAU PROTEIN
MONOCLONAL ANTIBODIES TARGETING MICROTUBULE-BINDING DOMAIN OF TAU PROTEIN
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机译:靶向单克隆抗体的Tau蛋白微管结合域
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摘要
Disclosed herein are monoclonal antibodies targeting specific tau epitopes, particularly, microtubule binding domain region 2 or region 4. Also disclosed herein are antibodies or antigen binding fragments thereof that specifically recognize a tau epitope consisting of the amino acid sequence of SEQ ID NO: 9 or 11. Also disclosed herein are methods of detecting tau protein in a subject, comprising performing an assay using the antibodies or antigen binding fragments thereof on the subject or on a biological sample obtained from the subject. Assay kits containing the disclosed antibodies are also provided. Further, methods of treating or preventing a tauopathy in a subject by administering to the subject tau antibodies or antigen-binding fragments thereof are provided.
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机译:本文公开了靶向特异性tau表位,特别是微管结合域区域2或区域4的单克隆抗体。本文还公开了特异性识别tau表位的抗体或其抗原结合片段,所述tau表位由SEQ ID NO:9或SEQ ID NO:9的氨基酸序列组成。 11.本文还公开了在受试者中检测tau蛋白的方法,其包括使用所述抗体或其抗原结合片段在所述受试者或从所述受试者获得的生物学样品上进行测定。还提供了包含所公开的抗体的测定试剂盒。此外,提供了通过向受试者施用tau抗体或其抗原结合片段来治疗或预防受试者的tau蛋白的方法。
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