ASEPTIC PROCESS FOR AZIDO-FUNCTIONALIZED LIGAND CONJUGATION TO SIZE-ISOLATED MICROBUBBLES VIA STRAIN-PROMOTED AZIDE-ALKYNE CYCLOADDITION

摘要

The current inventive technology includes system, methods and compositions for the generation of a cloaked microbubble having buried-ligand architecture (BLA) that may allow the cloaked microbubble to circumvent potentially deleterious immunogenic, or other unwanted chemical responses in a host. The current inventive technology may also includes systems and methods to isolate monodisperse size populations of microbubbles for enhanced therapeutic and diagnostic applications.