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RECOMBINANT ORGANISMS AND METHODS FOR PRODUCING GLYCOMOLECULES WITH HIGH GLYCAN OCCUPANCY
RECOMBINANT ORGANISMS AND METHODS FOR PRODUCING GLYCOMOLECULES WITH HIGH GLYCAN OCCUPANCY
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机译:重组有机物和高糖苷酸生产糖分子的方法
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摘要
The invention provides a recombinant Thraustochytriaceae cell for the production of a glycomolecule. The cell comprises a nucleic acid encoding a heterologous glycomolecule, and a sequence encoding a heterologous oligosaccharyltransferase. The cell produces the heterologous glycomolecule having a higher glycan occupancy compared to the same heterologous glycomolecule produced by a corresponding cell not comprising the heterologous oligosaccharyltransferase. The glycan occupancy can be more than 25%. The cells advantageously produce and, optionally secrete, the heterologous glycomolecule. Thus, the invention provides recombinant organisms that provide glycomolecules having a glycosylation profile that is more similar to the glycosylation profile produced in a mammalian cell.
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