p97 FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX

摘要

The invention relates to compounds having as homo- or heterocyclopentyl, cyclohexyl or cycloheptyl rings as pyrimidine fusion partners; An aminobenzyl or substituted aminobenzyl group at the 4-position of the pyrimidine ring; And a 5: 6 heterobicyclic ring having at least one N, O or S at the 2 position of the pyrimidine ring. These compounds are useful for the treatment of cancer by inhibiting the p97 complex.