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Separation and Purification Method for Vancomycin Hydrochloride of High Purity
Separation and Purification Method for Vancomycin Hydrochloride of High Purity
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机译:高纯度盐酸万古霉素的分离纯化方法
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摘要
The present invention relates to a method for producing a vancomycin product, which comprises the steps of (1) obtaining a vancomycin crude product as a vancomycin hydrochloride solution by ion exchange chromatography, desalting and concentrating it by nanofiltration to obtain a concentrated solution, (2) (3) collecting the chromatographic solution of vancomycin B to obtain a mixed chromatographic solution; (4) mixing the mixture with hydrochloric acid to obtain a mixed solution And then concentrating and removing the solvent and the salt by nanofiltration to obtain a concentrate; And (5) separating and purifying the high purity vancomycin hydrochloride, which comprises dehydrating and drying the concentrated liquid of step (4), or obtaining a pure vancomycin hydrochloride powder having an apparent purity of 99% by a solvent crystal or a salting-out method The method of the present invention not only improves the quality of the product but also is suitable for extended commercialization production.
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