Non-ERK MAPK pathway inhibitors - Methods and compositions for the treatment of resistant cancers

摘要

The present invention provides methods, pharmaceutical compositions and kits for treating or ameliorating the action of, in particular, cancer resistant or resistant to non-ERK MAPK pathway inhibitor therapy. Also provided is a method for identifying a subject with cancer that can benefit from treatment with an ERK inhibitor, and a method for inhibiting phosphorylation of RSK in a cancer cell that is resistant or resistant to a non-ERK MAPK pathway inhibitor.