NADPH Use of -nicotinamide adenine dinucleotide 2-phosphate reduced NADPH and its derivatives as beta-lactamase inhibitors

摘要

The present invention relates to a nucleotide functioning as a β-lactamase inhibitor and, specifically, to a novel use of a nicotinamide adenine dinucleotide phosphate (NADPH) and a derivative thereof. The present invention provides a β-lactamase inhibiting composition comprising one or more compounds selected from the group consisting of compounds i) to vii), or a pharmaceutically acceptable salt thereof. The compounds i) to vii) are: 1) a compound represented by chemical formula 1; ii) 3-acetylpyridine adenine dinucleotide (APAD); iii) flavin adenine dinucleotide (FAD); iv) β-nicotinamide adenine dinucleotide (NAD); v) a β-nicotinamide adenine dinucleotide reduced type (NADH); vi) β-nicotinamide adenine dinucleotide 2′-phosphate (NADP); and vii) a β-nicotinamide adenine dinucleotide 2′-phosphate reduced type (NADPH).