Nicotinamide adenine dinucleotide phosphate promote the rapid growth of the tumor

摘要

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is the main source of ROS (intracellular reactive oxygen species), ROS plays an important role in a variety of tumor, the ROS mediated by NADPH oxidase increase the expression of hypoxia inducing factor alpha(HIF-a) through multiple signaling pathways in tumor, and HIFcould be regulated and controlled by downstream multiple targeted genes such as vascular endothelial growth factor (VEGF), glucose transporter (GLUT) to promote tumor angiogenesis, cell energy metabolism reprogram and tumor metastasis.HIF-a, meanwhile, also can regulate the expression of NADPH oxidase by ROS, thus further promote development of tumor.In this review, we will summarize the functions of NADPH in tumorigenesis and discuss their potential implications in cancer therapy.