Methods for targeting oligonucleotides for HBV CCCDNA

摘要

The present invention provides oligonucleotide compositions targeting covalently linked cyclic (ccc) DNA of hepatitis B virus (HBV). Also disclosed herein are methods of treating a subject diagnosed or suspected of having an HBV infection and / or an HBV related disease, such as a chronic hepatitis B infection, liver failure or cirrhosis and hepatocellular carcinoma.