Oligonucleotide targeting strategy of HBV CCCDNA

摘要

The present disclosure provides oligonucleotide compositions that target hepatitis B virus (HBV) covalently closed circular (ccc) DNA. Also disclosed are methods for treating a subject diagnosed or suspected of having HBV infection and / or an HBV-related disorder, such as chronic hepatitis B infection, liver failure or cirrhosis, and hepatocellular carcinoma. The