- DRUG-LAYERED SILICATE COMPOSITE FOR ENHANCED ORAL BIOAVAILABILITY ORAL PHARMACOLOGICAL COMPOSITION INCLUDING THE DRUG-LAYERED SILICATE COMPOSITE AND METHOD OF MANUFACTURING THE DRUG-LAYERED SILICATE COMPOSITE

摘要

Disclosed is a drug-layered silicate composite. The drug-layered silicate composite comprise a sorafenib drug compound which is bound between a layered silicate powder and a silicate powder and exists in an amorphous state. When using such a composite, it is possible to remarkably improve internal absorption and bioavailability compared to an existing sorafenib compound.