Method for increasing thioredoxin expression of stem cells

摘要

The present invention relates to a method for upregulation of thioredoxin (TRX) expression in stem cells and, more particularly, to a method for upregulation of TRX expression in stem cells, the method comprising a step of culturing stem cells in a hypoxic condition, the stem cells having an upregulated expression of TRX by the same method, and a use of the stem cells in treatment of ischemic brain disease. When cultured in a hypoxic condition, stem cells are allowed to increase the expression of TRX and stem cells that have an upregulated expression level of TRX exhibiting an excellent therapeutic effect on ischemic brain disease can be obtained by the method. Thus, the stem cells can be usefully applied in the prevention or treatment of ischemic brain disease.