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Cosmetic composition containing anti-aging and wrinkle preventing pentapeptide and pentapeptide dimer production method

机译:含有抗衰老和防止皱纹的五肽化妆品组合物和五肽二聚体的生产方法

摘要

The present invention relates to a method for preparing a novel penta peptide and penta peptide dimer represented by the following Chemical Formulas 1 to 4 and to a cosmetic composition for preventing skin aging and preventing skin wrinkles containing the same as an active ingredient. Skin aging or skin with excellent effect of preventing skin aging or preventing skin wrinkles by increasing the amount of collagen type I and type II reduced collagen production in aged skin by including peptide and pentapeptide dimer as active ingredients It relates to a cosmetic composition for preventing and improving wrinkles. In particular, the pentapeptide and pentapeptide dimer for skin aging or wrinkle prevention and improvement can be used in addition to various basic cosmetic compositions such as skin, lotion, cream, essence, gel, pack or soap form, without skin irritation and skin Stability also has excellent characteristics. [Formula 1] [Cys-Gly-Gln-X-Arg] [Formula 2] Gly-X-Pro-Arg-Cys [Formula 3] [Cys-Gly-Gln-X-Arg] 2 [Formula 4] Gly-X-Pro-Arg-Cys 2 (In the formula 1 to 4, X is glutamic acid, aspartic acid, histidine, phenylalanine, alanine, cysteine, glycine, glutamine, asparagine, arginine, leucine, methionine, isoleucine, serine, tyrosine, threonine, lysine, tryptophan Selected from proline and valine, and [] 2 may represent a dimer of a cysteine residue, a thiol group (-SH), in a reduced form (-SS-).)
机译:本发明涉及一种制备由以下化学式1-4表示的新型五肽和五肽二聚体的方法,并涉及一种用于预防皮肤衰老和防止皮肤皱纹的化妆品组合物,其包含作为活性成分的五肽。通过增加肽和五肽二聚体作为活性成分,通过增加I型和II型胶原蛋白的量,具有防止皮肤衰老或防止皮肤皱纹的优异效果,从而可以防止皮肤衰老或皮肤皱纹。改善皱纹。特别地,除了皮肤,乳液,乳霜,香精,凝胶,包装或肥皂形式的各种基本化妆品组合物外,还可使用用于皮肤老化或预防和改善皱纹的五肽和五肽二聚体,也没有皮肤刺激性和皮肤稳定性。具有优良的特性。 [公式1] [Cys-Gly-Gln-X-Arg] [公式2] Gly-X-Pro-Arg-Cys [公式3] [Cys-Gly-Gln-X-Arg] 2 [式4] Gly-X-Pro-Arg-Cys 2 (在式1-4中,X是谷氨酸,天冬氨酸,组氨酸,苯丙氨酸,丙氨酸,半胱氨酸,甘氨酸,谷氨酰胺,天冬酰胺,精氨酸,亮氨酸,蛋氨酸,异亮氨酸,丝氨酸,酪氨酸,苏氨酸,赖氨酸,色氨酸选自脯氨酸和缬氨酸,[] 2可以还原形式表示半胱氨酸残基的二聚体,巯基(-SH) (-SS-)。

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