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PROCESS FOR EFFICIENT PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDES (HMO) FROM MICROBIAL FERMENTATION, HMO CONCENTRATE AND USE THEREOF
PROCESS FOR EFFICIENT PURIFICATION OF NEUTRAL HUMAN MILK OLIGOSACCHARIDES (HMO) FROM MICROBIAL FERMENTATION, HMO CONCENTRATE AND USE THEREOF
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机译:从微生物发酵,HMO浓缩物及其使用中高效纯化中性人乳寡糖(HMO)的方法
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摘要
FIELD: biotechnology.;SUBSTANCE: invention relates to biotechnology. Method for purification of neutral human milk oligosaccharides (HMO), HMO concentrate and use of HMO concentrate are disclosed. Method includes a combination of processing steps in cation- and anion-exchange devices for fermentation broth, comprising HMO obtained by microbiological fermentation of a recombinant microorganism, with a subsequent step of nanofiltration and/or electrodialysis and, optionally, a step for spraying drying thereof. HMO concentrate is obtained using said method. Concentrate is used in the prevention or treatment of gastrointestinal disorders.;EFFECT: inventions provide efficient purification of large quantities of neutral HMO.;18 cl, 3 dwg, 2 ex
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机译:技术领域:本发明涉及生物技术。公开了用于纯化中性人乳寡糖(HMO),HMO浓缩物的方法和HMO浓缩物的用途。该方法包括用于发酵液的阳离子交换和阴离子交换装置中的处理步骤的组合,其包括通过重组微生物的微生物发酵获得的HMO,随后是纳滤和/或电渗析的步骤,以及任选地,其喷雾干燥的步骤。 。使用所述方法获得HMO浓缩物。浓缩液用于预防或治疗胃肠道疾病。效果:发明提供了对大量中性HMO的有效纯化。18 cl,3 dwg,2 ex
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