BACTERIOPHAGE LYTIC ENZYME AND ANTIBACTERIAL COMPOSITION BASED THEREON

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to biotechnology, specifically to production of antibacterial recombinant proteins, and can be used in medicine as an antibacterial composition exhibiting activity against gram-negative bacteria Pseudomonas aeruginosa. A recombinant protein is obtained, which is covalently cross-linked endolysin of the antipseudomonal bacteriophage KRR10 and a modified fragment [K2,7,13]-SMAP-29(1-17) of myeloid antimicrobial sheep peptide SMAP-29.;EFFECT: invention provides higher effectiveness of antibacterial therapy against Pseudomonas aeruginosa bacteria.;2 cl, 7 dwg, 1 tbl, 3 ex