HYBRID AMIDES BASED ON TRIAZOLE AND THIAZOLIDINE HAVING ANTIMICROBIAL ACTIVITY

摘要

FIELD: medicine.;SUBSTANCE: invention relates to compounds of general formula (I) or a pharmaceutically acceptable salt thereof, where Z is independently selected and represents a fragment whose structural formula is given below, wherein the asterisk indicates an attachment point; X is independently selected and represents O or S; R¹ is independently selected and represents a benzylidene moiety optionally containing 1–3 substituents R', which is independently selected and represent -C_1-7-alkyl, -OC_1-7-alkyl, halogen, -OH, -C_5-7-cycloalkyl, -piperazinyl, optionally containing a substitute selected from -C_1-7-alkyl; wherein the asterisk indicates the substitution attachment point; R² is independently selected and represents H, -C_1-7-alkyl, phenyl; said phenyl in fragment R² is optionally substituted with at least two substitutes, which are halogen; R³ is independently selected and represents halogen; R⁴ is independently selected and represents halogen; n take values from 0 to 3. ; ;Z: , , , , , ;;R¹: .;EFFECT: disclosed compounds are intended for treating and/or preventing an infectious disease of microbial aetiology in a subject caused by a fungal infection, wherein the disease of the microbial aetiology is caused by fungi of the genus Candida speciales, Aspergillus speciales, Microsporum speciales, Trichophyton speciales and/or Epidermophyton speciales.;13 cl, 5 tbl, 56 ex