HYBRID ETHERS BASED ON DERIVATIVES OF THIAZOLIDINE-2,4-DIONA AND AZOLES (1H-1,3-IMIDAZOLE AND 1H-1,3,4-TRIAZOLE) AND APPLICATION THEREOF

摘要

FIELD: chemistry.;SUBSTANCE: invention relates to compounds of general formula (I) or (II), or a stereoisomer or enantiomer thereof, a pharmaceutically acceptable salt, wherein X is independently selected and is CH or N; Q is independently selected and is H, -C_1-6-alkyl, phenyl, halogenated phenyl, naphthyl or halogenated naphthyl; R₁, R₂, R₃, R₄ are independently selected and are H, -C_1-6-alkyl, -OH, halogen, -O-benzyl, phenyl, wherein the phenyl or benzyl can be optionally substituted with at least one substituent selected from halogen, -CN, -OH, -O-C_1-6-alkyl, -COOH, -COOC_1-6-alkyl, where R₁ and R₂ can form a bicyclic naphthyl moiety together with the cycle to which they are attached; R₅, R₆ are independently selected and are halogen. ; formula (I), ; formula (II).;EFFECT: according to the invention, the compounds are intended for treating and/or preventing an infectious disease of microbial etiology in a subject that is caused by a fungal infection.;23 cl, 8 tbl, 5 ex