TERAHERTZ SPECTROSCOPY FOR PREDICTING STABILITY OF AMORPHOUS DRUGS

摘要

A method for characterizing an amorphous material involves an evaluation of a rate of change with temperature of an interaction of the amorphous material with electromagnetic (EM) radiation. The interaction is at an energy of between 6.6×10−24 J and 6.6×10−21 J, which corresponds to EM radiation in the terahertz band, between 10 GHz and 10 THz. The rate of change of the interaction is evaluated in a temperature range below a glass transition temperature (Tg) of the amorphous material. The rate of change can then be compared with a predetermined value in order to characterize the amorphorphous material. An apparatus is provided to carry out the method, and the method can produce amorphous materials having desired properties, such as stability against crystallization.