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COMBINATION THERAPIES WITH FARNESOID X RECEPTOR (FXR) MODULATORS
COMBINATION THERAPIES WITH FARNESOID X RECEPTOR (FXR) MODULATORS
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机译:结合疗法与FARNESOID X受体(FXR)调节剂
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摘要
Described herein are methods of treating a metabolic disorder in an individual in need thereof, comprising co-administering to the individual a therapeutically effective amount of an FXR modulator, and at least one second agent that is an CCR2/CCR5 antagonist, ASKl inhibitor, DPP-IV inhibitor, caspase protease inhibitor, SGLT2 inhibitor, acetyl-CoA carboxylase (ACC) inhibitor, diacyl glycerol acyltransferase-1 inhibitor, sodium -bile acid cotransporter-inhibitor, TLR-4 antagonist, PPAR alpha/delta agonist, or GLP-1 agonist, or a combination thereof.
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