首页> 外国专利> METHOD FOR PREDICTING EFFECT OF DAIKENCHUTO AND METHOD FOR DETERMINING DOSAGE OF DAIKENCHUTO

METHOD FOR PREDICTING EFFECT OF DAIKENCHUTO AND METHOD FOR DETERMINING DOSAGE OF DAIKENCHUTO

机译:预测大池虫效果的方法和确定大池虫剂量的方法

摘要

Provided are a method for predicting the effect of Daikenchuto, a method for determining the dosage of Daikenchuto, etc. using an objective index by a method for predicting the effectiveness of Daikenchuto in a patient characterized by including the following steps (a) and (b): (a) a step of determining the ratio of the phylum Bacteroidetes to the phylum Firmicutes (B m /F m ratio) in the intestine of the patient by analyzing the intestinal flora of the patient; and (b) a step of determining the effectiveness of Daikenchuto in the patient by comparison with criteria such that when the B m /F m ratio is lower than a reference value, Daikenchuto is more effective, and when the B m /F m ratio is higher than a reference value, Daikenchuto is less effective, and a method for determining the dosage of Daikenchuto for a patient characterized by including the following steps (a) and (e): (a) a step of determining the ratio of the phylum Bacteroidetes to the phylum Firmicutes (B m /F m ratio) in the intestine of the patient by analyzing the intestinal flora of the patient, and (e) a step of determining the dosage of Daikenchuto for the patient by decreasing the dosage of Daikenchuto for the patient when the B m /F m ratio determined in the step (a) is a lower value than a reference value, and increasing the dosage of Daikenchuto for the patient when the B m /F m ratio is a higher value than a reference value.
机译:本发明提供一种通过预测以下的步骤(a),(b)为特征的患者中的预测效果的方法,使用客观指标来预测代金中毒的效果的方法,确定代金中毒的剂量的方法等。 ):(a)通过分析患者的肠道菌群来确定患者肠道中拟杆菌门与硬毛门的比率(B m / F m比)的步骤; (b)通过与标准相比较来确定Daikenchuto对患者的有效性的步骤,使得当B m / F m比低于参考值时,Daikenchuto更有效,以及当B m / F m比时大于参考值,Daikenchuto效果较差,一种确定患者Daikenchuto剂量的方法,其特征在于包括以下步骤(a)和(e):(a)确定门的比例的步骤通过分析患者的肠道菌群来鉴定患者肠道菌群中的拟杆菌(B m / F m比率),以及(e)通过减少以下药物的剂量来确定患者的Daikenchuto剂量的步骤当步骤(a)中确定的B m / F m比值低于参考值时,患者;当B m / F m比值高于参考值时,为患者增加Daikenchuto的剂量值。

著录项

  • 公开/公告号EP3438273A4

    专利类型

  • 公开/公告日2019-12-18

    原文格式PDF

  • 申请/专利权人 TSUMURA & CO.;

    申请/专利号EP20170774327

  • 发明设计人 NISHIYAMA MITSUE;

    申请日2017-03-15

  • 分类号C12Q1/02;C12Q1/68;G01N33/48;C12N1/20;

  • 国家 EP

  • 入库时间 2022-08-21 11:41:04

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