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MODIFIED BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION
MODIFIED BINDING PROTEINS INHIBITING THE VEGF-A RECEPTOR INTERACTION
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机译:抑制VEGF-A受体相互作用的修饰结合蛋白
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摘要
The present invention relates to binding proteins specific for VEGF-A, in particular to recombinant binding proteins comprising a polyethylene glycol moiety and a binding domain, which inhibits VEGF-Axxx binding to VEGFR-2. Examples of such recombinant binding proteins are proteins which comprise an ankyrin repeat domain with the desired binding specificity, and a polyethylene glycol moiety. The binding proteins are useful in the treatment of cancer and other pathological conditions, e.g. eye diseases such as age-related macular degeneration.
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