To find a substance that is able to normalize abnormal blood vessels in tumors without affecting normal blood vessels, and provide a novel use of the substance.SOLUTION: A leukocyte infiltration promoter and a tumor immunoactivator are provided each of which comprises a lysophospholipid receptor-activating substance as an active ingredient, and having the action of promoting infiltration of leukocytes into the whole region of a tumor.SELECTED DRAWING: None
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