GENETICALLY MODIFIED IMMUNE EFFECTOR CELLS AND GENETICALLY ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS

摘要

To provide improved T-cells and CAR constructs that allow for control of in vivo persistence.SOLUTION: The present invention provides a genetically engineered antigen presenting cell (APC) comprising a transgene encoding a target antigen and a transgene encoding human leukocyte antigen (HLA). In some aspects, the genetically engineered APC may additionally include one or more transgenes encoding a costimulator (e.g., IL-15). Such genetically engineered APCs may be used, for example, in methods for expansion of T cells (e.g., CAR T cells) ex vivo, or may be administered to a control in order to stimulate the growth of antigen-specific T cells in vivo. Thus, the cells provided herein may be used to stimulate the growth of antigen-specific T cells to treat a disease (e.g., cancer).SELECTED DRAWING: None