Peptide compounds, conjugate compounds and their use for the treatment of inflammatory diseases

摘要

The present disclosure relates to peptide and conjugate compounds, processes, methods and their use for treating inflammation. For example, the compound is a compound for use in inhibiting or reducing TNF-α-induced COX-2 expression in saltyrin-expressing cells; IKLSGGGVQAKAGVINMDKSSM of SEQ ID NO: 5 (V), SEQ ID NO: 10. GVRAKAGVRN (Nle) FKSEY of formula (X) and YKSLRRRKAPRWDAPLRDPALRQLL of formula (XI) of SEQ ID NO: 11 can be included, and at least one protecting group and / or at least one labeling agent is N and / or It is linked to the peptide compound at the C-terminus. [Selection diagram] FIG. 17