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Method for measuring ADAMTS13-mediated in vivo cleavage of von Willebrand factor and uses thereof
Method for measuring ADAMTS13-mediated in vivo cleavage of von Willebrand factor and uses thereof
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机译:测量ADAMTS13介导的von Willebrand因子体内裂解的方法及其用途
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摘要
The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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