Giant self-heating alkali metal or alkaline earth metal-doped iron oxide nanoparticles in a biocompatible alternating magnetic field and method for producing the same

摘要

The iron oxide nanoparticles of the present invention are synthesized by high-temperature pyrolysis of an Fe3 + precursor and an M + or M2 + precursor (M = Li, Na, K, Mg, Ca) in an atmosphere containing oxygen, and the Fe3 + vacancy of γFe2O3 (Vacancy site) doped with alkali metal (alkali metal ion) or alkaline earth metal (alkali earth metal ion) so that it generates explosive heat even in a biocompatible low AC magnetic field. Become. Both in vitro and in vivo experiments have demonstrated that cancer cells can be killed by performing low-frequency hyperthermia treatment using the iron oxide nanoparticles of the present invention. [Selection diagram] Fig. 1