Iron oxide nanoparticles doped with alkali metals or alkali earth metals capable of gigantic AC magnetic self-heating in biocompatible AC magnetic field and method of preparing the same

摘要

Disclosed herein are iron oxide nanoparticles prepared through high-temperature thermal decomposition of an Fe³⁺ precursor and an M⁺ or M²⁺ (M=Li, Na, K, Mg, and Ca) precursor in an oxygen atmosphere. The iron oxide nanoparticles are nanoparticles, in which an alkali metal or alkali earth metal is doped into an Fe vacancy site of γ-Fe₂O₃, and generate explosive heat even in a biocompatible low AC magnetic field. Through both in vitro and in vivo tests, it was proven that cancer cells could be killed by performing low-frequency hyperthermia using the iron oxide nanoparticles set forth above.