Mutant histidine decarboxylase and its use

摘要

The present invention provides a mutant histidine decarboxylase suitable for practical use. Specifically, the present invention provides a mutant histidine decarboxylase, wherein at least one amino acid residue of the wild-type histidine decarboxylase is mutated, and the histidine decarboxylase activity and / or stability is higher than that of the wild-type histidine decarboxylase. Histidine decarboxylase; and use thereof. The mutant histidine decarboxylase has motifs (1) to (6), and it is preferable that the amino acid residue in at least one of these motifs has a mutation. It is also preferred that the mutant histidine decarboxylase has a mutation of one or more amino acid residues in the amino acid sequence represented by SEQ ID NO: 3 and a sequence homologous thereto.