首页> 外国专利> Cell population containing fetal appendix-derived adherent cells, method for producing the same, and pharmaceutical composition

Cell population containing fetal appendix-derived adherent cells, method for producing the same, and pharmaceutical composition

机译:包含胎儿阑尾来源的贴壁细胞的细胞群,其制备方法和药物组合物

摘要

An object of the present invention is to provide a cell population containing fetal appendage-derived adherent cells having low differentiation ability, a method for producing the same, and a pharmaceutical composition containing the above cell population. According to the present invention, there is provided a method for producing a cell population containing fetal accessory cell-derived adherent cells, the method comprising obtaining a cell population having the following cell characteristics (a) and (b): (A) In the cell population, the ratio of fetal appendage-derived adherent cells that are positive for CD73 and CD90 is 90% or more, and (b) the cell population is the LFA-3 gene with respect to the SDHA gene expression level. That the relative expression level is 1.0 or more is provided.
机译:本发明的目的是提供含有分化能力低的胎儿附肢来源的贴壁细胞的细胞群,其制造方法以及含有上述细胞群的药物组合物。根据本发明,提供了一种产生含有胎儿辅助细胞来源的贴壁细胞的细胞群的方法,该方法包括获得具有以下细胞特征(a)和(b)的细胞群:(A)在在细胞群体中,对CD73和CD90呈阳性的胎儿附肢来源的贴壁细胞的比例为90%或更高,并且(b)相对于SDHA基因表达水平,细胞群体是LFA-3基因。提供相对表达水平为1.0或更高。

著录项

  • 公开/公告号JPWO2018186418A1

    专利类型

  • 公开/公告日2020-02-20

    原文格式PDF

  • 申请/专利权人 株式会社カネカ;

    申请/专利号JP20190511267

  • 发明设计人 稲生 渓太;喜田 悠太;

    申请日2018-04-03

  • 分类号C12N5/071;A61P37/06;A61P37/08;A61P9/10;A61P13/12;A61P25;A61P11;A61P1/04;A61P29;A61P17;A61P17/06;A61P1/16;A61P3/10;A61P35;A61P19/02;A61P27/02;A61P9;A61P9/04;A61P17/02;A61K35/50;A61K35/51;A61L27/36;

  • 国家 JP

  • 入库时间 2022-08-21 11:31:53

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