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Administration of NEDD8-activating enzyme inhibitor and chemotherapeutic agents
Administration of NEDD8-activating enzyme inhibitor and chemotherapeutic agents
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机译:NEDD8活化酶抑制剂和化学治疗剂的给药
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摘要
Disclosed are methods for the treatment of various solid tumors in patients in need of such treatment. The methods comprise administering to such a patient an NEDD8-activating enzyme (NAE) inhibitor such as ((1S,2S,4R)-4-(4-((1S)-2,3-dihydro-1H-inden-1-ylamino)-7H-pyrrolo[2,3-d]-pyrimidin-7-yl)-2-hydroxycyclopentyl)methyl sulfamate (MLN4924) or a pharmaceutically acceptable salt in combination with one or more chemotherapeutic agents. Also disclosed are medicaments for use in the treatment of various solid tumors.
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