Various techniques are described to compensate for weather and other extraneous temperature conditions along a transit route when preparing a product for cold-chain shipment packaging. The origin and destination of the shipment may be determined to calculate one or more transit routes, which may include each stage along each transit route. Weather data may be received from one or more sources to build a weather database for one or more locations, which may be used to generate a temperature profile indicating the expected temperature and duration at each stage of transit to which the cold-chain shipment will be exposed. Thermodynamic calculations may then be performed in accordance with the temperature profile to determine the best available packaging option to prevent the product's temperature from falling outside of a desired or mandatory cold-chain temperature range.
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