UPCONVERSION NANOPARTICLE, HYALURONIC ACID-UPCONVERSION NANOPARTICLE CONJUGATE, AND A PRODUCTION METHOD THEREOF USING A CALCULATION FROM FIRST PRINCIPLES

摘要

An upconversion nanoparticle includes at least one host selected from LiYF₄, NaY, NaYF₄, NaGdF₄, and CaF₃, at least one sensitizer selected from Sm³⁺, Nd³⁺, Dy³⁺, Ho³⁺, and Yb³⁺ doped in the at least one host, and at least one activator selected from Er³⁺, Ho³⁺, Tm³⁺, and Eu³⁺ doped in the at least one host. The upconversion nanoparticle is designed using a calculation from first principles to absorb light in the near-infrared wavelength range whose stability is ensured. Further, a hyaluronic acid-upconversion nanoparticle conjugate, in which the upconversion nanoparticle as described above is bonded to hyaluronic acid, is provided to be used in various internal sites with a hyaluronic acid receptor, particularly enables targeting, and increases an internal retention period and biocompatibility thereof.