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Coating of Nanoparticle Surfaces with Cyclopeptides for Improving Delivery of Agents Via the Oral Route
Coating of Nanoparticle Surfaces with Cyclopeptides for Improving Delivery of Agents Via the Oral Route
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机译:用环肽包覆纳米颗粒表面,以改善通过口服途径传递药物的作用
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摘要
The present invention relates to a surface-coated nanoparticle comprising biodegradable polymer chains and cyclopeptides, wherein the cyclopeptides are covalently attached to the biodegradable polymer chains forming the nanoparticle, thereby coating the surface of the nanoparticle. The present invention further relates to the use of said surface-coated nanoparticle as a capsule for an agent for improving the oral delivery thereof. In another aspect, the present invention relates to the surface-coated nanoparticle for use in the treatment or prevention of a disorder or disease in a patient, wherein the treatment or prevention is achieved by mucosal uptake of the surface-coated nanoparticle via the oral route.
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