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SCORPION VENOM HEAT-RESISTANT SYNTHETIC PEPTIDE AND APPLICATIONS THEREOF
SCORPION VENOM HEAT-RESISTANT SYNTHETIC PEPTIDE AND APPLICATIONS THEREOF
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机译:蝎子毒耐热合成肽及其应用
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摘要
A scorpion venom heat-resistant synthetic peptide (SVHRSP) contains an amino acid sequence of SEQ ID NO 1. One or more amino acids the amino acid sequence can be substituted or deleted. A pharmaceutical composition that contains the SVHRSP has numerous applications. The pharmaceutical composition can be used to protect neuronal cell against amyloid beta-induced toxic effects, or to inhibit the sodium channel current of a hippocampal neuronal cell, or to protect a neuronal cell against NMDA-induced injury. It may also promote the formation of a pluripotent neural stem cell from a type II astrocyte, or treats a subject, such as a human, having epilepsy, Alzheimer's disease, or Parkinson's disease.
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机译:蝎毒耐热合成肽(SVHRSP)包含一个SEQ ID NO 1的氨基酸序列。一个或多个氨基酸可以被取代或缺失。包含SVHRSP的药物组合物具有许多应用。该药物组合物可用于保护神经元细胞免受淀粉样β诱导的毒性作用,或抑制海马神经元细胞的钠通道电流,或保护神经元细胞免受NMDA诱导的损伤。它还可以促进由II型星形胶质细胞形成多能神经干细胞,或治疗患有癫痫,阿尔茨海默氏病或帕金森氏病的受试者,例如人。
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