PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING PRURITUS, CONTAINING PYRAZOLE DERIVATIVE AS ACTIVE INGREDIENT, AND SCREENING METHOD FOR DETECTING SAME

摘要

The present invention relates to a pharmaceutical composition for preventing or treating pruritus, containing a pyrazole derivative as an active ingredient, and a screening method for detecting the same. A pharmaceutical composition for preventing or treating pruritus, according to the present invention, can relieve the symptoms of pruritus by inhibiting the activity of intracellular Mrgpr X1, and can relieve the symptoms of pruritus by inhibiting the activity of intracellular hH1R, thereby being usable also as a medicine for preventing or treating histamine-mediated pruritus. In addition, it has been confirmed through dry skin mouse model experimentation that the composition also has significant alleviation effects on dry skin, thereby being usable as a medicine for treating dry skin. Furthermore, the pharmaceutical composition according to the present invention can relieve the symptoms of pruritus caused by psoriasis, thereby being usable also as a medicine for treating psoriasis. Moreover, the pharmaceutical composition according to the present invention can maintain stable activity, even during in vivo drug administration, without causing adverse reactions.