Pharmaceutical composition containing a pyrazole derivative as an active ingredient for preventing or treating pruritus, and a screening method for detecting the same

摘要

The present invention relates to a pharmaceutical composition containing a pyrazole derivative as an active ingredient for preventing or treating pruritus, and a screening method for detecting the same. The pharmaceutical composition for preventing or treating pruritus according to the present invention can alleviate the symptoms of pruritus by inhibiting the activity of intracellular Mrgpr X1 and also inhibit the activity of intracellular hH1R. The symptom of pruritus can be relieved by this, and it can be used also as a pharmaceutical for preventing or treating histamine-mediated pruritus. Furthermore, it has been confirmed from a dry skin mouse model experiment that the above composition also has a significant reducing effect on dry skin, whereby it can be used as a drug for treating dry skin. . Furthermore, the pharmaceutical composition according to the present invention can alleviate the symptoms of pruritus caused by psoriasis, and thus can be used as a medicament for treating psoriasis. Furthermore, the pharmaceutical composition according to the present invention can maintain stable activity without causing adverse reactions even during drug administration in vivo. [Selection diagram] Fig. 7