首页>
外国专利>
A pharmaceutical composition for preventing or treating pruritus, which contains a pyrazole derivative as an active ingredient, and a screening method for detecting it.
A pharmaceutical composition for preventing or treating pruritus, which contains a pyrazole derivative as an active ingredient, and a screening method for detecting it.
展开▼
机译:用于预防或处理瘙痒的药物组合物,其含有吡唑衍生物作为活性成分,以及用于检测其的筛选方法。
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to a pharmaceutical composition for preventing or treating pruritus, containing a pyrazole derivative as an active ingredient, and a screening method for detecting the same. A pharmaceutical composition for preventing or treating pruritus, according to the present invention, can relieve the symptoms of pruritus by inhibiting the activity of intracellular Mrgpr X1, and can relieve the symptoms of pruritus by inhibiting the activity of intracellular hH1R, thereby being usable also as a medicine for preventing or treating histamine-mediated pruritus. In addition, it has been confirmed through dry skin mouse model experimentation that the composition also has significant alleviation effects on dry skin, thereby being usable as a medicine for treating dry skin. Furthermore, the pharmaceutical composition according to the present invention can relieve the symptoms of pruritus caused by psoriasis, thereby being usable also as a medicine for treating psoriasis. Moreover, the pharmaceutical composition according to the present invention can maintain stable activity, even during in vivo drug administration, without causing adverse reactions.
展开▼