COMPOSITIONS AND METHODS OF CONTROLLING EXPRESSION OF THERMOGENIN (UCP-1) IN SKELETAL MUSCLES

摘要

Described herein are pharmaceutical compositions containing genes encoding a positive regulatory domain zinc finger protein 16, a peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein, and a bone morphogenetic protein 7. Also disclosed are methods of treating or managing obesity and diabetes by delivering these pharmaceutical compositions using ultrasound-targeted microbubble destruction.