it is a human food supplement that comprises theacrine and optionally other compounds that modulate the effects of theacrine. Uses for the theatrine-containing supplement include improving at least one among mood, energy, focus, concentration or sexual desire or a reduction of at least one among anxiety or fatigue. a synergistic composition comprises co-administration of theacrine and caffeine, with co-administered caffeine reducing oral theacrine clearance (cl / f) and oral volume of distribution (vd / f). in addition, coadministered caffeine increases the area under the (auc) time curve of plasma theacrine concentration, and increases the maximum plasma concentration of theacrine (cmax) compared to pharmacokinetic parameters when teacrine is administered alone.
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