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METHODS OF ASSESSMENT OF HOMOLOGICAL RECOMBINATION DEFICIENCY AND PREDICTION OF RESPONSE TO CANCER TREATMENT
METHODS OF ASSESSMENT OF HOMOLOGICAL RECOMBINATION DEFICIENCY AND PREDICTION OF RESPONSE TO CANCER TREATMENT
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机译:同源重组缺陷的评估方法和对癌症治疗反应的预测
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摘要
This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of homologous recombination deficiency (HRD) or an HRD signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an HRD signature are provided. Materials and methods for identifying cells (e.g., cancer cells) having a deficiency in homology directed repair (HDR) as well as materials and methods for identifying cancer patients likely to respond to a particular cancer treatment regimen also are provided.
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