APPLICATION OF SEMAPHORIN-4D-BINDING MOLECULES FOR TREATMENT OF NEURODEGENERATIVE DISORDERS

摘要

Methods for alleviating symptoms in a subject having a neurodegenerative disorder are provided, comprising administering to the subject an effective amount of an isolated binding molecule that specifically binds to semaphorin 4D (SEMA4D) or its receptors plexin-B1 and plexin-B2. In addition, an isolated binding molecule is provided that specifically binds to the same SEMA4D epitope as the reference monoclonal antibody selected from the group consisting of VX15 / 2503 and 67.