COMBINATIONS CONTAINING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR 2 SUBTYPE, AND THEIR APPLICATION

摘要

The present invention relates to combinations comprising a positive allosteric modulator ("PAM") of a metabotropic glutamatergic subtype 2 receptor ("mGluR2") or a pharmaceutically acceptable salt or solvate thereof or a compound representing an orthosteric agonist of a metabotropic glutamatergic subtype 2 receptor, or a pharmaceutically acceptable salt thereof or a solvate and ligand, which is a synaptic vesicle protein 2A ("SV2A").