FcRn-BINDING ABOLISHED ANTI-IGF-1R ANTIBODIES AND THEIR USE IN THE TREATMENT OF VASCULAR EYE DISEASES

摘要

The invention provides an anti-IGF-1R antibody that specifically binds to the human IGF-1R with abolished FcRn-binding, a method and the use thereof for the treatment of vascular eye diseases, a corresponding pharmaceutical composition and a method and the use of this antibody for inhibiting angiogenesis in the eye in an individual by inhibiting IGF-1R mediated signaling.